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Magnetic resonance imaging studies of patients included in a Phase 1B/2A clinical trial showed slowing of the rate of decline in hippocampal volume in the treated group and evidence of increased hippocampal volume in APOE4 gene carriers

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Ann Rheum Dis 72(7):11251135.10.1136/annrheumdis-2012-202745 [DOI] [PubMed] 44.Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P, American College of R (2012) American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

The gutbrain axis is a bidirectional hormonal and neural signaling pathway connecting the gut and the brain