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The organising principle On average, insulin resistance tends to improve most through (1) movement, (2) body fat reduction where appropriate, and (3) reducing glucotoxicity

This has been demonstrated in human peripheral blood mononuclear cells, where exenatide blocked NF-kB binding to DNA and downregulated both TNF and IL-1 beta expression

Bryan Johnson stirred up a ton of interest when he started a microdosing experiment about a year ago [1]
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