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Description
This may suggest the possibility that the short-acting nature of GLP-1 activation enhancement was insufficient to reduce the occurrence of CV events, beyond improved glycemic metabolism

The gradual dosage titration schedule (starting at lower doses) helps minimize these effects

This happens because the medication helps regulate appetite and metabolism, and once its discontinued, your body may gradually revert to its previous patterns
Transdermal patch: a novel approach for transdermal drug delivery
