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Methodological limitations of existing research include: Observational study designs that cannot establish causationindividuals prescribed GLP-1 agonists may differ systematically from comparison groups Confounding variables such as concurrent lifestyle interventions, psychological support, or other medications Short follow-up periods that do not capture long-term outcomes or relapse patterns Publication bias , with positive findings more likely to be reported than null results Safety considerations are paramount

10.1016/j.neuint.2019.04.010 [DOI] [PMC free article] [PubMed] [Google Scholar] 11.Ma J, Shi M, Zhang X, Liu X, Chen J, Zhang R, Wang X, Zhang H (2018) GLP1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NFkappaB signaling pathways in streptozotocininduced diabetic rats

Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) deliver effective glycaemic control with a low risk of hypoglycaemia, while increasing satiety, reducing body weight and blood pressure and improving cardiovascular disease (CVD) outcomes [3,4,5]