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The data from recent research indicates that supplementation with 10% fructans in male C57BL/6J mice demonstrates action [15]
25 The mechanisms of action of weight loss for these drugs, which range from diverse activities on the hypothalamus (e.g., mesolimbic reward system) to direct activity on the intestines (e.g., lipase inhibition), are reviewed in detail elsewhere 26

Circulation 2018;138:12-24
