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Many men notice that, with increased testosterone, their appetite is better regulated

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The most common adverse effects of tirzepatide are gastrointestinal, including nausea (occurring in 15-30% of patients), diarrhea, vomiting, constipation, and abdominal discomfort

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According to Truveta Research presented at ISPOR 2025, side effects were the leading reason patients stopped taking GLP-1 medications, accounting for 28.2% of all discontinuations

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