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Liraglutide has also been reported to cross the BBB to a limited extent, with pharmacologically relevant concentrations detected in discrete regions such as the hypothalamus and brainstem [66,70]

2021 Jul 20;13(7):2473

The relative benefits of canagliflozin for cardiovascular outcomes were similar in individuals across the spectrum of eGFR levels (155) DECLARETIMI 58 Trial The effect of dapagliflozin on cardiovascular events has been reported (156)