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Lower doses reach lower steady states, which may be sufficient for some goals while inadequate for others

had current treatment with or history of (within 3 months before visit 2) treatment with medications that may cause substantial weight gain, including but not limited to: tricyclic antidepressants, atypical antipsychotics and mood stabilizers Examples: imipramine amitriptyline mirtazapine paroxetine phenelzine chlorpromazine thioridazine clozapine olanzapine valproic acid (and its derivatives) or lithium Note: selective serotonin reuptake inhibitors other than paroxetine were permitted

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The SURMOUNT-1 trial data is revealing