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Instead of waiting for volume loss to show up, we work with patients from the start of their GLP-1 journey
The authors compared changes in glycemic control and BMD with and without conversion from DPP-4 inhibitor to GLP-1 receptor agonist for 3 years and observed that patients who switched to the latter had greater decline in lumbar BMD than controls regardless of weight loss [12, 61]
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It tracks into adult cardiometabolic disease, carries psychosocial burden, and responds poorly to lifestyle intervention alone in many patients
