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Studies have shown that GLP-1 agonists can trigger effects in the brain, the heart, the liver, the pancreas, the stomach, and the musclesmeaning that they could have implications for conditions other than type 2 diabetes and obesity, such as heart disease, kidney disease, liver disease, and even neurological conditions such as Alzheimer's disease

For me, that was a game changer, Mitchell said

and that any discrepancies from the study as originally planned (and, if relevant, registered) have been explained

El agonismo GIP potencia el efecto incretnico y anorexiante de GLP-1 a nivel central, reduciendo el desarrollo de nuseas (tabla 2)1,3,5