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Once it reaches the bloodstream, it is directly inactivated within seconds by the enzyme dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between positions 8 and 9, converting it into the truncated form GLP-1(936) amide

This effect was consistent across different administration routes (oral vs

Peak appetite suppression, the strongest reduction in hunger and food-related thinking, typically occurs around weeks 12 to 14 at therapeutic doses

How The Study Was Built The investigators used the TriNetX US Collaborative Network and identified 841,831 eligible adult women with breast cancer across 68 healthcare organizations