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It may also synergize with existing therapies to amplify GLP-1 signaling and reduce medication dosages, while preserving islet cell function in high-risk individuals
Dramatic, rapid weight loss in the first few weeks often signals too aggressive a starting dose
In a patient with high-risk conditions like atrial fibrillation, previous thromboembolism, LV dysfunction, hypercoagulable condition, and older-generation mechanical valve, a goal INR of 3.0 (2.5 to 3.5), similar to MVR is recommended
