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Description
The First Wave: Older GLP-1 Medications Before semaglutide stole the spotlight, several other GLP-1 agonists were used primarily for diabetes management, with modest weight loss benefits

Improving insulin sensitivity : This can contribute to more stable blood sugar levels, which is beneficial for both weight management and overall metabolic health
Semaglutide features a substitution of alanine residue with a non-coded amino acid, 2-aminoisobutyric acid (Aib) at position 8, shielding against DPP-4-mediated N-terminal proteolysis while preserving GLP-1R affinity (96)

CDSCO has approved semaglutide for prescription by endocrinologists and internal medicine specialists for diabetes and obesity indications
