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You can read the abstract of this article at In a Phase 3 trial involving 1879 individuals with type 2 diabetes (T2D) on metformin, Tirzepatide (TZP) at doses of 5 and 15 mg demonstrated substantial improvements in HbA1c and weight reduction compared to 1 mg of semaglutide (SEMA)

If palpitations persist, your doctor may review all your medications to rule out interactions or side effects

Results might be noticeable in a few weeks, but often, real weight loss requires six months to a year of regular use

Whether the GLP-1 receptors have "reset" during the time on tirzepatide depends on factors that have not been well studied, including how long the tirzepatide period lasted, individual receptor biology, and the doses used