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The primary mechanisms of action include: Enhancing insulin secretion from the pancreas in response to elevated blood glucose levels, which helps lower blood sugar Suppressing glucagon release , a hormone that raises blood glucose Slowing gastric emptying , which means food moves more slowly from the stomach into the small intestine Reducing appetite through effects on brain centres that regulate hunger and satiety These combined effects make GLP-1 receptor agonists effective for glycaemic control in type 2 diabetes and, for those specifically licensed for weight management, achieving significant weight loss

Though early work from companies like Vertex (Semma Tx acquisition) are focused on regeneration of pancreatic islets (for diabetes), Novo Nordisk recently inked a deal (including $75M upfront) with early-stage cell therapy player Aspect Biosystems

Instead of acting on appetite hormones, it blocks some fat absorption in the digestive tract

That way, you know what counts, what resets, and what kind of play correlates with realistic outcomes