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Pugazhenthi U, Velmurugan K, Tran A, Mahaffey G, Pugazhenthi S (2010) Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients

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16 During normal muscle physiology at rest, ion channels (including Na + /K + pumps and Na + /Ca 2+ exchangers) located on the plasma membrane (sarcolemma) maintain low intracellular Na + and Ca 2+ concentrations and high K + concentrations within the muscle fiber