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Instead, neuronal GLP-1Rs located outside the BBB primarily serve as peripheral targets for gut-derived or pharmacologically administered GLP-1 (Varin et al., 2019
doi: 10.1007/s40618-015-0404-6 29 HabibZAHavstadSLWellsKDivineGPladevallMWilliamsLK

Candidates should be willing to engage in concurrent lifestyle modifications, including dietary changes and increased physical activity, as medications work most effectively when combined with behavioral interventions

Preclinical evidence suggests 30%40% more weight loss than with a single GLP-1 agonist
