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For non-diabetic obesity, the cleanest comparison is between two separate trials: STEP 1 (semaglutide 2.4 mg, Wilding et al., NEJM 2021): 14.9% body weight loss at 68 weeks SURMOUNT-1 (tirzepatide 15 mg, Jastreboff et al., NEJM 2022): 20.9% body weight loss at 72 weeks A roughly 6 percentage point gap in average weight loss favors tirzepatide

In this regard, GLP-1RAs have shown promising efficacy as to the improvement of hard cardiovascular outcomes with cardiovascular safety

Taking the Wegovy pill and levothyroxine close together increases how much thyroxine you absorb, and losing weight reduces how much levothyroxine your body needs, so both tend to lower your dose

Chakravarthy says