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In a clinical trial called SURMOUNT-5, researchers compared the two medications directly
The 8mg dose achieved 21.1% weight loss (matching Zepbounds efficacy) with lower side effects: 24% nausea versus 28% at 12mg, 8.4% discontinuation versus 11.2%
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This physical sensation of fullness, combined with reduced hunger hormones (particularly ghrelin suppression), creates a compounding effect that makes overeating unlikely and weight loss sustainable
