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Nevertheless, important uncertainties remain, including the degree of brain penetrance across individual agents, the relative contributions of central versus peripheral mechanisms, biomarkers of target engagement, and the patient subgroups most likely to benefit

GLP-1 RAs are currently being explored for use in various new areas, such as cardiovascular disease, non-alcoholic steatohepatitis (NASH), Alzheimer's disease, and chronic kidney disease

However, your healthcare provider may prescribe microdosing depending on your body tolerance

5 Even modest weight loss is clinically meaningful: reductions of 5% of baseline weight can improve blood pressure, glucose levels and cardiovascular risk