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Protocol for a randomized phase II/III double-blind placebo-controlled trial to evaluate the safety and efficacy of extended-release metformin in amnestic mild cognitive impairment: metformin in Alzheimer dementia prevention (MAP)

Professional bodies like The Obesity Society and endocrine societies recommend considering medications like Saxenda or Wegovy for patients with BMI 30 (or 27 with comorbidities) who have not achieved weight loss goals with lifestyle changes alone ( [145] ) ( [146] )

These participants had baseline HbA1c levels of 9.0% or lower (Supplemental Fig

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