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Specific symptoms that should prompt medical consultation include an irresistible urge to move the legs, especially when accompanied by uncomfortable sensations such as crawling, pulling, tingling, or aching deep within the leg muscles

While -blockers are effective antihypertensive agents, concerns have been raised regarding their potential adverse effects on metabolic parameters such as lipid profiles and insulin sensitivity, as well as their propensity to induce weight gain in some individuals (Pischon and Sharma, 2001)

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One retreatment: Patients receive 1 additional course of semaglutide following an off-treatment period