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Fermented Foods : Probiotics in yoghurt and kefir may indirectly support GLP-1 production
Am J Transplant 12(6):15761583
Whereas the DPP-IV degradation can be avoided by substituting Ala 8 with various amino acids like Gly, Ser, d-Ala, and Aib, 32,37 the degradation by NEP 24.11 is hard to address in a similar manner because of the multiple sites that NEP 24.11 targets (Figure 1)
This is evidenced by up-regulation of glycolytic enzyme expression, increased rates of glucose uptake and consumption, as well as augmented ATP content, insulin secretion and glycolytic flux after removal of Exendin-4
