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10.1007/s10620-017-4470-9 17 CaiW.SakaguchiM.KleinriddersA.Gonzalez-Del PinoG.DreyfussJ

These findings provided a better understanding of the physiology of GLP-1 and the pharmacology of its analogues and have revolutionized the management of obesity and several comorbidities

These signaling pathways regulate many downstream targets such as glycogen synthase kinase 3 (GSK3-B) and FOXO1, which are involved in pathological processes of PD, promoting an antiapoptotic cell survival pathway
In addition, in a report of six cases of patients with PWS and T2D never treated with GH, the treatment with 1.2 to 1.8 mg/day of liraglutide, a long-acting GLP-1R agonists, or 20 mg/day of exenatide for two years, a trend to reduced HbA1c and mean blood glucose, BMI, and waist circumference [23]
