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Site-specific knockdown of GLP-1R in the MHb or pharmacological antagonism of GLP-1Rs in the IPN increased nicotine intake and restored preference for nicotine-paired environments

Other medications such as somatostatin analogues, diazoxide, and GLP-1R agonists also are used based on sporadic case reports (25)

The release of GLP-1 from nutrient stimulation is ultimately dependent upon calcium influx, but macronutrients likely differ in their signaling mechanisms (Fig