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In recent years, the mechanism of action and therapeutic applications of GLP-1R have received extensive attention, especially in the field of diabetes and obesity treatment (Zheng et al., 2024)

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A 2024 study from Epic Research found that people with hypothyroidism who lost more than 5 pounds while taking GLP-1 medications (including semaglutide) saw TSH (thyroid-stimulating hormone) levels decrease by an average of about 0.55 mU/L
