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Secondary analyses of these studies suggested that weight loss might be the main driver of GLP-1RA efficacy in MASH, supported by the lack of expression of GLP-1 receptors in the human liver 93

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Following the application of inclusion criteria (peer-reviewed studies, systematic reviews, meta-analyses and preclinical or clinical studies in English) and excluding conference abstracts, non-peer-reviewed material and studies lacking mechanistic or therapeutic relevance, a final set of 124 studies was included