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10.1023/A:1011918719017 [DOI] [PubMed] [Google Scholar] 21.Chou JZ, Place GD, Waters DG, Kirkwood JA, Bowsher RR

So any strength training two to three times a week, and light aerobic activity. Resistance training is the most effective strategy for preserving muscle mass during weight loss, advises Snyder

This approach maintains the average caloric deficit required for fat loss while providing muscles with the nutrients they need on the days they need them most

Published clinical trials have reported large average body weight reductions in obesity protocols, dose dependent HbA1c and weight changes in type 2 diabetes protocols, and liver fat imaging endpoints in defined substudies, which is why retatrutide is now a major reference point in modern metabolic peptide research