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Description
Studies have shown that activation of the GLP1 receptor downregulates the expression of NADPH oxidase NOX3 and mitochondrial superoxide dismutase SOD2, thereby reducing ROS levels, blocking the oxidative stress-induced upregulation of Beclin1 expression and increased LC3-II/I ratio, and delaying autophagosome formation [57]
Following the conclusion of the respiration protocol, the samples were collected from the chambers and stored at 20 C for further analysis
Participants received the maximum tolerated dose of either medication for 72 weeks
Am J Physiol Endocrinol Metab 308: E583E591
