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However, due to the ability of the drugs to improve fertility in women with obesity, and their ability to reduce effectiveness of the oral contraceptive pill due to delayed gastric emptying, there are a rapidly increasing number of cases of exposure to GLP1RAs in early pregnancy where women have become pregnant while taking one of the drugs

No large-scale clinical trials have studied microdosing specifically

But the arrival of generics is not a signal to relax

The compound faces bioavailability challenges, and some users report that effects vary significantly between batches, possibly due to stability issues