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Call 999 or go to A&E immediately if you experience: Severe allergic reactions, including facial swelling, difficulty breathing, or severe itching Chest pain or fainting episodes Severe abdominal pain with persistent vomiting Contact your GP or NHS 111 urgently if you experience: Severe or persistent vomiting or diarrhoea lasting more than 24 hours, as this increases dehydration risk and may prevent adequate medication absorption Diarrhoea containing blood or mucus , particularly if accompanied by fever or severe abdominal cramping, as this could indicate C