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For most patients, gastrointestinal side effects like nausea significantly improve or resolve completely within 23 months as tolerance develops

Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes

Side effects that should be reported to a healthcare provider as soon as possible include: Allergic reactions such as rash, itching, or swelling of the face, lips, or tongue Breathing problems Bloody or black stools Symptoms of kidney stones (blood in urine or lower back pain) Symptoms of liver injury such as yellowing of the skin or eyes Trouble passing urine Uncontrolled or urgent bowel movements Vomiting Side effects that may not require medical attention include:[2] Gas Increased bowel movements Oily stools Upset stomach Ozempic Ozempic is a medication injected once weekly into the thigh, abdomen, or upper arm