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Cardiovascular Risk Reduction: Beyond Weight and Diabetes The LEADER, SUSTAIN-6, and REWIND trials established that GLP-1 agonists reduce major adverse cardiovascular events in patients with established heart disease or multiple risk factors

By week 48, many users report minimal or absent nausea despite therapeutic appetite suppression continuing

Known as a "triple agonist," retatrutide acts on three key hormone receptors: GLP-1, GIP, and GCG

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