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doi: 10.1007/s11011-021-00879-1 [DOI] [PubMed] [Google Scholar] 97

Jujic A, Nilsson PM, Atabaki-Pasdar N, Dieden A, Tuomi T, Franks PW, Holst JJ, Torekov SS, Ravassa S, Diez J, et al

However, this relationship does not account for the differences in HR increases within the sub-class of the long-acting agents

Despite the positive results, due to the limited number of included studies, further randomized controlled trials are needed to investigate the safety and efficacy of SGLT2i and GLP-1RAs as first-line treatment options for patients with T2DM at low cardiovascular disease risk, particularly when compared to metformin