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These results highlight how difficult it is for adolescents to keep weight off once they lose it. Those taking exenatide had an increase of 8 bpm in heart rate from randomization to 1 year compared with a 1 bpm increase for placebo ( P = .03)

Do not freeze the medication, and discard any pen that has been frozen or left out longer than recommended

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GLP-1 receptors are expressed in key reward-related brain regions , including: The ventral tegmental area (VTA) and nucleus accumbens , which form the core of the mesolimbic dopamine pathway The prefrontal cortex , involved in executive function and impulse control The amygdala , which processes emotional salience and stress responses The prevailing hypothesis suggests that GLP-1 receptor activation may modulate dopamine signalling in reward circuits