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As presented at the American Diabetes Association Meeting: this randomized phase 2b trial in 230 adults with overweight or obesity shows that aleniglipron, an oral small-molecule GLP1-RA, led to up to 11.3% body-weight loss compared with placebo after 36 weeks of treatment.

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The researchers were able to measureGLP-1 in synovial fluid - the liquid within joint cavities - of patients with inflammatory rheumatic diseases. That matters becauseGLP-1-based therapies typically lead to much higher systemic exposure