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Longitudinal Targeted Minimum Loss-based Estimation, a method that adjusts for both baseline and time-varying confounding, was used to estimate absolute risks of cardiovascular outcomes under sustained use of GLP1-RA and DPP 4i (active comparator), adjusting for baseline and time-varying confounding

The change, advocates argue, would curb rising obesity rates, reduce health care disparities and save on health care costs.

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GLP-1 and DPP-4 inhibitors can be used together in specific clinical scenarios, though combination therapy requires careful provider evaluation