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Kidney Problems Some GLP-1 drugs have been linked to kidney issues, including: Acute kidney injury Worsening of chronic kidney disease Patients with pre-existing kidney conditions should be closely monitored while on GLP-1 therapy

Native GLP-1 functions as a rapid-response, meal-related hormone with a half-life measured in minutes, while semaglutide is an engineered therapeutic agent with a half-life measured in days

The research versus pharmaceutical grade comparison also matters here, because pharmaceutical-grade formulations often come pre-reconstituted at standardized concentrations, eliminating the calculation step entirely

Thirdly, we assessed for heterogeneity of treatment effects across the range of the propensity score by categorising propensity score into tenths based on the distribution among GLP-1 receptor agonist users and including an interaction term between the exposure variable and propensity score tenth in our regression model.37 To assess the robustness of our findings, we did six sensitivity analyses