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Glucagon-like peptide-1 (GLP-1) receptor agonists like liraglutide and semaglutide are effective treatments for weight loss in adults with obesity and have several cardiovascular benefits

In addition, the multivalency of dual- and triple-agonists supports the development of nanocarriers with enhanced avidity, promoting receptor clustering and downstream signaling without requiring increased systemic exposure [99]

Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Insulin Glargine as Add-on to Metformin (With or Without Sulfonylureas) in Insulin-Naive Patients With Type 2 Diabetes (SUSTAIN 4): A Randomised, Open-Label, Parallel-Group, Multicentre, Multinational, Phase 3a Trial

Common side effects including nausea, vomiting, constipation, and fatigue may temporarily reduce sexual desire, particularly during treatment initiation or dose escalation