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Common adverse effects include nausea, vomiting, diarrhea, and constipation, which are generally dose-dependent and often improve with continued use

The use of pharmacology and molecular genetics led to the identification of the arcuate nucleus, which contains the orexigenic neuropeptide Y (NPY)/agoutirelated protein (AGRP) and anorexic proopiomelancortin (POMC) cells

Despite this conservation, these peptides induce distinct signalling profiles and have different mechanisms for receptor interaction 4

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