fda glp-1 warning letters october 2025 CDER Jump 50% in FY — What That Means for Industry FDA Issues Warning Letters Against
Description
Safety and tolerability of glucagon-like peptide-1 receptor agonists: unresolved and emerging issues

Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans

Across all studies, approximately 1066 participants are involved, with enrollment ranging from smaller pilot studies involving 3070 participants to larger trials enrolling over 100 participants, with some phase III trials reaching as high as 188 participants
Of these, 63 articles were excluded based on various reasons, as demonstrated in Supplementary Material 2
