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Abbreviations AA: Acetic acid AIM2: Absent-in-melanoma 2 Akt: Protein kinase B ALP: Alkaline phosphatase AMP: Adenosine monophosphate AMPK: AMP-activated protein kinase AQP2: Aqua porin proteins ARE: Antioxidant response element system ATP: Adenosine 5-triphosphate Bax: BCL-2-associated X protein BCL-2: B-cell lymphoma 2 BMDM: Bone marrow-derived macrophages BMP: Bone morphogenetic protein C1P: Ceramide-1-phosphate Ca + 2 : Calcium CAC: Colitis-associated cancer cAMP: Adenosine 3,5-cyclic monophosphate CAT: Catalase CD: Crohns disease CD62: Cluster of differentiation 62 CDX2: Caudal type homeobox 2 Cer: Ceramide cGMP: Guanosine 3,5-cyclic monophosphate CoQ10: Coenzyme Q10 COX-2: Cyclooxygenase-2 cPLA2: Cytosolic phospholipase A2 CRBST: Carbosisteine CREB: CAMP response element-binding protein CRP: C-reactive protein CTGF: Connective tissue growth factor DAI: Disease activity index DKK1: Dickkopf-related protein 1 DPP-IV: Dipeptidyl peptidase IV DSS: Dextran sulfate sodium ECM: Extracellular matrix EMT: Epithelial-mesenchymal transition ERK: Extracellular signal-regulated kinase FDA: Food and Drug Administration FOXP3: Forkhead box protein p3 GM-CSF: Granulocytemacrophage colony-stimulating factor gp: Glycoprotein GPX4: Glutathione peroxidase 4 GSH: Glutathione HCAECs: Human coronary artery endothelial cells HIMFs: Hypoxia-induced mitogenic factors HMG-CoA: 3-Hydroxy-3-methylglutaryl coenzyme A HO-1: Heme oxygenase-1 HSP70: Heat shock protein IBD: Inflammatory bowel disease ICAM1: Intercellular adhesion molecule-1 IFN: Interferon IFN-: Interferon-alpha IGF-I/II: Insulin-like growth factors-I/II IL: Interleukin IL IL-1: Interleukin-1 IL-10: Interleukin-10 IL-18: Interleukin 18 IL-6: Interleukin 6 IL-6R: IL6 receptor iNOS: Inducible nitric oxide synthase JAK: Janus kinase JNK: C-Jun N-terminal kinase KLF4: Krppel-like factor 4 LDL: Low-density lipoprotein lncRNAs IFNG-AS1: Long noncoding RNA interferon-gamma antisense RNA 1 LPS: Lipopolysaccharide LRR: Leucine-rich repeat MATH: Mouse atonal homolog 1 MCP-1: Monocyte chemoattractant protein-1 M-CSF: Macrophage colony-stimulating factor MDA: Malondialdehyde miR-146a: MicroRNA-146a MPO: Myeloperoxidase mRNA: Messenger ribonucleic acid mTOR: Mammalian target of rapamycin mTORC1: MTOR complex 1 mTORC2: MTOR complex 2 MyD88: Myeloid differentiation primary response 88 NF-B: Nuclear factor kappa B NLR: LRR-containing proteins NLRP3: NLR family pyrin domain containing 3 NO: Nitric oxide NOD: Nucleotide-binding oligomerization domain NQO-1: NAD(P)H/quinone acceptor oxidoreductase-1 Nrf2: Nuclear factor erythroid-2 related factor 2 PDEs: Phosphodiesterases PGE2: Prostaglandin E2 PGE2: Prostaglandin E2 PI3K: Phosphoinositol-3-kinase PKA: Protein kinase A PMA-THP-1: Phorbol-12-myristate-13-acetate-activated human monocytic cell line PMS: Partial Mayo score PPAR: Peroxisome proliferator-activated receptors PRR: Pattern recognition receptor PTX: Pentoxifylline PXR: Pregnane X receptor RNS: Reactive nitrogen species ROS: Reactive oxygen species S1P: Sphingosine-1-phosphate S1PRs15: Five G protein-coupled receptors SDF: Stromal cell-derived factor SLC7A11: Solute carrier family 7 member 11 SMILE: Small heterodimer partner-interacting leucine zipper protein SOD: Superoxide dismutase SPH: Sphingosine SPHK: Sphingosine kinase STAT3: Signal transducer and activator of transcription 3 TCA: T cell activation gene TGFR1: TGF- receptor1 TGFR2: TGF- receptor2 TGF-: Transforming growth factor-beta Th1: T-helper type 1 cell Th2: T-helper type 2 cell TIMPs: Tissue inhibitors of metalloproteinases TJ: Tight junction TJs: Tight junctions TLR: Toll-like receptor TNBS: 2,4,6-Trinitrobenzenesulfonic acid TNF: Tumor necrosis factor TSC2: Tuberous sclerosis protein 2 UC: Ulcerative colitis ULK1: Unc-51 like autophagy activating kinase 1 VEGF: Vascular endothelial growth factor ZO-1: Zonula occludens-1 References Abdallah DM, El-Abhar HS (2021) Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-kB/HMGB-1 trajectories Abdelhamid AM, Youssef ME, Cavalu S, Mostafa-Hedeab G, Youssef A, Elazab ST et al (2022) Carbocisteine as a modulator of Nrf2/HO-1 and NFB interplay in rats: new inspiration for the revival of an old drug for treating ulcerative colitis

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