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In clinical trials of obese patients, tirzepatide showed even more impressive results in terms of weight loss from baseline, with an average reduction of 20-24%, and in some cases more than 30%, and became the first drug to outperform bariatric surgery (surgical procedures on the stomach and intestines aimed at treating obesity) in terms of effectiveness in studies
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By contrast, metformin appears to exert broader effects on pathways directly implicated in AD pathogenesis, including AMPK, insulin, and adipocytokine signaling
