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Zhang T, Perkins MH, Chang H, Han W, de Araujo IE
Conceptual history of the nigrostriatal dopamine system
In fact, a quinoxaline (compound 2) and a pyrimidine (compound B) act in an additive manner to activate the GLP-1R under conditions in which the receptor is truncated to remove the N-terminal extracellular domain at which the C-terminus of GLP-1 binds
The primary endpoint (a composite of cardiovascular death or heart failure hospitalization) was significantly reduced: 9.9% of tirzepatide patients vs 15.3% of placebo patients had an event
