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Dosing is titrated based on patient tolerance and response

While neither tirzepatide nor niacinamide requires routine dose adjustment for hepatic impairment, patients with severe liver disease should be monitored closely if treatment is deemed necessary by the prescribing provider

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Zepbound is administered as a once-weekly subcutaneous injection, with dosing typically starting at 2.5 mg for 4 weeks, then increasing by 2.5 mg every 4 weeks as tolerated (through intermediate steps of 5 mg, 7.5 mg, 10 mg, 12.5 mg) to a maintenance dose of 5 mg, 10 mg, or 15 mg based on individual response and tolerability