short acting glp 1 agonists GLP-1 and Diabetes Mellitus Evolution of GLP‐1 Receptor Agonists
Description
Recent Developments In February 2026 , Pfizer announced positive Phase 2b trial results for its ultra-long-acting injectable GLP-1 (PF-08653944), demonstrating significant weight loss with monthly dosing

GLP-1 Cantini et al

doi:10.1074/jbc.M303509200 73

These findings support semaglutide 2.4 mg as an effective therapeutic option for weight and fat mass reduction while preserving, or potentially improving, muscle function and metabolic health