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Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression

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The World Health Organisation's 2026 global guidelines on GLP-1 therapies for obesity explicitly recommend combining medication with intensive behavioural interventions, including structured goal-setting for diet and physical activity

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GLP-1 receptor agonists like semaglutide show mixed effects on mental health outcomes in clinical studies

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