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Food and Drug Administration approved the first GLP-1 medications in 2005

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[DOI] [PMC free article] [PubMed] [Google Scholar] [118].Trujillo JM, Nuffer W, Ellis SL, GLP-1 receptor agonists: a review of head-to-head clinical studies, Ther Adv Endocrinol Metab, 6 (2015) 1928

The FDA classifies semaglutide and tirzepatide as controlled medications because they require medical oversight to ensure safe dosing and monitoring
