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PubMed Coskun T, et al

Biomarkers like fasting insulin, HbA1c, and adiponectin levels at baseline predict treatment responsiveness better than demographics alone
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Synthetic GLP-1 drugs each have their own modification that allows them to slip by DPP-4 or survive longer in the blood

These neurological effects reduce hunger signals and food cravings, contributing substantially to the weight loss observed in clinical trials
