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It should not be construed as medical advice or self-medication

* Clinically Meaningful Reduction:Both interventions exceeded the minimum clinically important difference (MCID) for pain on the Numerical Rating Scale (NRS)

Collectively, these players represent a diverse pipeline that extends beyond GLP-1 into new mechanisms and address unmet needs in T2D management

For instance, exendin-4 has been shown to ameliorate the high glucose-induced fibronectin (FN) and type I collagen (Col1) expression in tubular epithelial cells by inhibiting the secretion of miR-192, an microRNA (miRNA) that is regulated by p53 and plays a role in renal fibrosis (Li et al., 2018)